Study Reveals Genetic Heritage May Influence Dengue Severity

Recent research suggests that genetic ancestry can affect how the human body responds to the dengue virus. Conducted by scientists from the University of Pittsburgh, UPMC, and the Aggeu Magalhães Institute, the study found that individuals with African lineage tend to exhibit a more controlled inflammatory response, while those with European ancestry show stronger reactions, potentially increasing the risk of complications.

By analyzing human skin samples, researchers observed that people with predominantly European genetic traits experienced more severe inflammation and higher viral replication. In contrast, individuals of African descent showed a more balanced immune response, which helped limit viral multiplication and reduced the likelihood of severe illness.

This discovery underscores the importance of considering genetic factors in countries with high ethnic diversity. Populations historically exposed to mosquito-borne viruses may have developed more effective defense mechanisms, yet everyone remains vulnerable to infection.

As Aedes aegypti continues to spread globally, understanding how genetic factors influence dengue severity is crucial for improving prevention strategies and tailoring treatments. Despite differences in immune responses across populations, combating the mosquito remains essential. Eliminating breeding sites and investing in sustainable solutions continue to be the most effective ways to curb the disease worldwide.